GM-CSF: the secret weapon in the T(H)17 arsenal
- PMID: 21587311
- DOI: 10.1038/ni.2044
GM-CSF: the secret weapon in the T(H)17 arsenal
Abstract
Identification of the pathogenic cytokines that underlie the IL-23-dependent disease progression of experimental autoimmune encephalomyelitis has proven elusive. Evidence now points to GM-CSF.
Comment on
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The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.Nat Immunol. 2011 Jun;12(6):568-75. doi: 10.1038/ni.2031. Epub 2011 Apr 24. Nat Immunol. 2011. PMID: 21516111 Free PMC article.
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RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.Nat Immunol. 2011 Jun;12(6):560-7. doi: 10.1038/ni.2027. Epub 2011 Apr 24. Nat Immunol. 2011. PMID: 21516112
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