Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990;80(3):189-94.
doi: 10.1007/BF01245120.

Antinociceptive effects of the stereoisomers of nicotine given intrathecally in spinal rats

M K Christensen  1 , D F Smith
Affiliations

Antinociceptive effects of the stereoisomers of nicotine given intrathecally in spinal rats

M K Christensen et al. J Neural Transm Gen Sect. 1990.

Abstract

Spinalized rats received an intrathecal injection of either (-)-nicotine or (+)-nicotine in order to study the stereoselectivity of antinociception. Pain threshold was measured using the tail-flick test. Both stereoisomers had anti-nociceptive effects, but (-)-nicotine was up to 970 times more potent, depending on test conditions. The antinociceptive action of (-)-nicotine was antagonized by mecamylamine and yohimbine but not by naloxone and atropine. The findings show that spinal mechanisms are highly stereoselective toward nicotine, and suggest that primarily nicotinergic and alpha-adrenergic receptors are involved in its central antinociceptive effects.

PubMed Disclaimer

References

    1. Naunyn Schmiedebergs Arch Pharmacol. 1976;292(2):119-26 - PubMed
    1. Eur J Pharmacol. 1980 Jan 25;61(2):111-24 - PubMed
    1. Neuropharmacology. 1987 Oct;26(10):1453-5 - PubMed
    1. Eur J Pharmacol. 1982 Apr 8;79(1-2):129-33 - PubMed
    1. J Pharmacol Exp Ther. 1949 Jun;96(2):99-113 - PubMed

LinkOut - more resources