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. 2010 Sep 6;2(2):e14.
doi: 10.4081/pr.2010.e14.

Liver transplantation in Greek children: 15 years experience

Ioannis Xinias  1 , Antigoni Mavroudi, Olga Vrani, Georgios Imvrios, Dimitrios Takoudas, Kleomenis Spiroglou
Affiliations

Liver transplantation in Greek children: 15 years experience

Ioannis Xinias et al. Pediatr Rep. .

Abstract

Liver transplantation (LT) is the only available live-saving procedure for children with irreversible liver failure. This paper reports our experience from the follow-up of 16 Greek children with end-stage liver failure who underwent a LT. Over a period of 15 years, 16 pediatric liver recipients received follow up after being subjected to OLT (orthotopic liver transplantation) due to end-stage liver failure. Nine children initially presented with extrahepatic biliary atresia, 2 with acute liver failure after toxic mushroom ingestion, 2 with intrahepatic cholestasis, 2 with metabolic diseases and one with hepatoblastoma. Ten children received a liver transplant in the Organ Transplantation Unit of Aristotle University of Thessaloniki and the rest in other transplant centers. Three transplants came from a living-related donor and 13 from a deceased donor. Six children underwent immunosuppressive treatment with cyclosporine, mycophenolate mofetil and corticosteroids, and 7 with tacrolimus, mycophenolate mofetil and corticosteroids. Three out of 16 children died within the first month after the transplantation due to post-transplant complications. Three children presented with acute rejection and one with chronic organ rejection which was successfully managed. Five children presented with cytomegalovirus infection, 5 with Epstein-Barr virus, 2 with HSV(1,2), 2 with ParvoB19 virus, 2 with varicella-zoster virus and one with C. Albicans infection. One child presented with upper gastrointestinal hemorrhage and one with small biliary paucity. A satisfying outcome was achieved in most cases, with good graft function, except for the patient with small biliary paucity who required re-transplantation.The long-term clinical course of liver transplanted children is good under the condition that they are attended in specialized centers.

Keywords: Greek children.; liver transplantation.

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Figures

Figure 1
Figure 1
Causes (%) of liver failure in our cases.
Figure 2
Figure 2
Survival rates of the liver transplanted patients over the last 15 years.
See this image and copyright information in PMC

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