Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jun;11(1):53-7.
doi: 10.1007/s10158-011-0118-1. Epub 2011 May 18.

Single-channel recording from adult Brugia malayi

Alan P Robertson  1 , Sreekanth Puttachary, Richard J Martin
Affiliations

Single-channel recording from adult Brugia malayi

Alan P Robertson et al. Invert Neurosci. 2011 Jun.

Abstract

Lymphatic filariasis is a significant cause of morbidity in humans. One of the causative agents is Brugia malayi a clade III nematode. Current therapeutic agents are effective against the microfilaria but less so against the adults residing in the host lymphatics. A large number of anthelmintics act on nematode ion channels including the nicotinic receptors found on nematode somatic muscle. The purpose of this study was to develop a preparation from adult B. malayi that was amenable to patch-clamp recording to facilitate the study of the ion channels present in this organism. We also present a preliminary characterization of the single-channel properties of nicotinic receptors from the adult musculature.

PubMed Disclaimer

References

    1. Acta Trop. 2005 Apr;94(1):1-14 - PubMed
    1. FASEB J. 2006 Dec;20(14):2606-8 - PubMed
    1. N Z Vet J. 2010 Jun;58(3):121-9 - PubMed
    1. J Membr Biol. 1993 Jan;131(2):143-9 - PubMed
    1. J Exp Biol. 1990 Nov;154:201-21 - PubMed

Publication types

LinkOut - more resources