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Editorial
. 2011 Jul 1;10(13):2055-6.
doi: 10.4161/cc.10.13.15805. Epub 2011 Jul 1.

Division of labor of the replication fork protection complex subunits in sister chromatid cohesion and Chk1 activation

Eishi Noguchi
Editorial

Division of labor of the replication fork protection complex subunits in sister chromatid cohesion and Chk1 activation

Eishi Noguchi. Cell Cycle. .
No abstract available

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Figure 1. Separation of functions between Timeless (Tim) and Tipin (Tip). The replication fork may stall at cohesin-bound sites. ssDNA accumulated at stalled forks is coated by RPA bound by Tipin and ATRIP, which recruit Timeless and ATR, respectively. Tipin also recruits Claspin to mediate the ATR-Chk1-dependent checkpoint, resulting in cell cycle arrest. Timeless interacts with cohesins at the fork to help sister chromatid cohesion, while it facilitates the re-start of stalled replication forks.
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