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. 1990 Mar;9(1):51-5.
doi: 10.1007/BF02030242.

Superoxide anion production by circulating polymorphonuclear leucocytes in rheumatoid arthritis

A Cencetti  1 , M De Martino, E Graziani, S Maddali Bongi, C Palermo, E Pavari, M Zoppi
Affiliations

Superoxide anion production by circulating polymorphonuclear leucocytes in rheumatoid arthritis

A Cencetti et al. Clin Rheumatol. 1990 Mar.

Abstract

In twelve rheumatoid arthritis (RA) patients, receiving only nonsteroid anti-inflammatory therapy, superoxide anion (02-) generation by polymorphonuclear leucocytes (PMNs) was assessed by Cytochrome C reduction. The 02- production by non-activated PMNs in RA patients was significantly higher than in healthy controls. The 02- production by PMNs activated by zymosan and phorbol myristate acetate was significantly lower than in controls. PMNs from controls preincubated with rheumatoid sera generated higher 02- levels than the same PMNs incubated in normal sera.

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