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Comment
. 2011 Jul;20(7):1097-9.
doi: 10.1002/pro.660.

Allostery turns 50: is the vintage yet attractive?

Maurizio Brunori  1
Affiliations
Comment

Allostery turns 50: is the vintage yet attractive?

Maurizio Brunori. Protein Sci. 2011 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Energy level diagram indicating the 10 states (T0to T4 and R0 to R4) and the fundamental equilibrium constants of the MWC model, namely: KT and KR, the oxygen dissociation constants of the two allosteric states T(tense) and R (relaxed); and L0, the population ratio of the two states in the fully deoxygenated tetrameric hemoglobin. Drawings depict the two different quaternary states; the assumption implicit is the fully concerted quaternary transition which (in the specific case of a symmetric binding curve) occurs at the level T2–R2 (switch-over point). Typical values of the parameters for human hemoglobin at neutral pH and 20 °C are approximately: L0 = [T0]/[R0] = 105, and c = KR/KT = 0.01.
See this image and copyright information in PMC

Comment on

References

    1. Monod J, Wyman J, Changeux J-P. On the nature of allosteric transitions: a plausible model. J Mol Biol. 1965;12:88–118. - PubMed
    1. Changeux J-P. 50th anniversary of the word “allosteric”. Protein Sci. 20:1119–1124. (in press) - PMC - PubMed
    1. Buc H. Interactions between Jacques Monod and Jeffries Wyman (or the burdens of co-authorship) In: Brunori M, Careri G, Changeux J-P, Schachman HK, editors. Vol. 17. Rend Fis Acc Lincei; 2006. pp. 31–49. Allosteric Proteins.
    1. Monod J, Changeux J-P, Jacob F. Allosteric proteins and cellular control systems. J Mol Biol. 1963;6:306–329. - PubMed
    1. Perutz MF, Rossmann MG, Cullis AF, Muirhead H, Will G, North ACT. Structure of hæmogloba three-dimensional Fourier synthesis at 5.5-Å. resolution, obtained by X-ray analysis. Nature. 1960;185:416–422. - PubMed

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