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. 1990 Jun;64(6):3078-81.
doi: 10.1128/JVI.64.6.3078-3081.1990.

Evidence suggesting that virulence maps to the P1 region of the coxsackievirus B4 genome

A Ramsingh  1 , A Hixson, B Duceman, J Slack
Affiliations

Evidence suggesting that virulence maps to the P1 region of the coxsackievirus B4 genome

A Ramsingh et al. J Virol. 1990 Jun.

Abstract

A chimeric virus containing the P1 region of a virulent variant of coxsackievirus B4 and the P2 and P3 regions of a nonvirulent strain was constructed from cDNA clones. The chimeric virus induced pancreatitis with concurrent hypoglycemia similar to that observed in mice infected with the virulent variant.

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