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. 2011 May 20:6:51.
doi: 10.1186/1748-717X-6-51.

Clinical outcomes of chemoradiotherapy for locally recurrent rectal cancer

Joo Ho Lee  1 , Dae Yong Kim, Sun Young Kim, Ji Won Park, Hyo Seong Choi, Jae Hwan Oh, Hee Jin Chang, Tae Hyun Kim, Suk Won Park
Affiliations

Clinical outcomes of chemoradiotherapy for locally recurrent rectal cancer

Joo Ho Lee et al. Radiat Oncol. .

Abstract

Background: To assess the clinical outcome of chemoradiotherapy with or without surgery for locally recurrent rectal cancer (LRRC) and to find useful and significant prognostic factors for a clinical situation.

Methods: Between January 2001 and February 2009, 67 LRRC patients, who entered into concurrent chemoradiotherapy with or without surgery, were reviewed retrospectively. Of the 67 patients, 45 were treated with chemoradiotherapy plus surgery, and the remaining 22 were treated with chemoradiotherapy alone. The mean radiation doses (biologically equivalent dose in 2-Gy fractions) were 54.6 Gy and 66.5 Gy for the chemoradiotherapy with and without surgery groups, respectively.

Results: The median survival duration of all patients was 59 months. Five-year overall (OS), relapse-free (RFS), locoregional relapse-free (LRFS), and distant metastasis-free survival (DMFS) were 48.9%, 31.6%, 66.4%, and 40.6%, respectively. A multivariate analysis demonstrated that the presence of symptoms was an independent prognostic factor influencing OS, RFS, LRFS, and DMFS. No statistically significant difference was found in OS (p = 0.181), RFS (p = 0.113), LRFS (p = 0.379), or DMFS (p = 0.335) when comparing clinical outcomes between the chemoradiotherapy with and without surgery groups.

Conclusions: Chemoradiotherapy with or without surgery could be a potential option for an LRRC cure, and the symptoms related to LRRC were a significant prognostic factor predicting poor clinical outcome. The chemoradiotherapy scheme for LRRC patients should be adjusted to the possibility of resectability and risk of local failure to focus on local control.

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Figures

Figure 1
Figure 1
Overall survival (a) and relapse-free survival (b) between the chemoradiotherapy with surgery and without surgery groups.
See this image and copyright information in PMC

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