Stay tuned: miRNA expression and nonsense-mediated decay in brain development
- PMID: 21596305
- DOI: 10.1016/j.molcel.2011.05.002
Stay tuned: miRNA expression and nonsense-mediated decay in brain development
Abstract
In this issue of Molecular Cell (Bruno et al., 2011), regulation of the key nonsense-mediated RNA decay (NMD) proteins UPF1 and MNL51 (BTZ) by miRNA 128 is discovered to fine-tune gene expression in brain differentiation, thus documenting a novel cooperation of two posttranscriptional mechanisms of gene regulation in developmental decision making.
Copyright © 2011 Elsevier Inc. All rights reserved.
Comment on
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Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay.Mol Cell. 2011 May 20;42(4):500-10. doi: 10.1016/j.molcel.2011.04.018. Mol Cell. 2011. PMID: 21596314 Free PMC article.
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