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Comment
. 2011 May 20;42(4):411-2.
doi: 10.1016/j.molcel.2011.05.001.

"Competence" progress

David F Stern  1
Affiliations
Comment

"Competence" progress

David F Stern. Mol Cell. .

Abstract

Zwang et al. (2011) have identified outputs of two EGF pulses that commit cells to cycle. The first induces components for lipid biosynthesis and sets up an inhibitory latch through p53. The second works through ERK to EGR1 and releases the latch to promote restriction point traverse.

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References

    1. Balciunaite E, Kazlauskas A. The timing and extent of activation of diacylglycerol-responsive protein kinase-cs determines their ability to inhibit or promote platelet-derived growth factor-dependent DNA synthesis. Exp Cell Res. 2002;281:167–174. - PubMed
    1. Dou QP, Levin AH, Zhao S, Pardee AB. Cyclin E and cyclin A as candidates for the restriction point protein. Cancer Res. 1993;53:1493–1497. - PubMed
    1. Jones SM, Klinghoffer R, Prestwich GD, Toker A, Kazlauskas A. PDGF induces an early and a late wave of PI 3-kinase activity, and only the late wave is required for progression through G1. Curr Biol. 1999;9:512–521. - PubMed
    1. Kazlauskas A. The priming/completion paradigm to explain growth factor-dependent cell cycle progression. Growth Factors. 2005;23:203–210. - PubMed
    1. Leof EB, Wharton W, van Wyk JJ, Pledger WJ. Epidermal growth factor (EGF) and somatomedin C regulate G1 progression in competent BALB/c-3T3 cells. Exp Cell Res. 1982;141:107–115. - PubMed