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Comment
. 2011 May 20;332(6032):923-5.
doi: 10.1126/science.1207552.

Cell biology. The TASCC of secretion

Roberto Zoncu  1 , David M Sabatini
Affiliations
Comment

Cell biology. The TASCC of secretion

Roberto Zoncu et al. Science. .
No abstract available

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Figures

Figure 1
Figure 1. The TASCC enhances synthesis and secretion of SMS components during Ras-induced senescence
In normal cells growing in nutrient-rich medium (left) autophagy is suppressed, among other mechanisms, by mTORC1-mediated phosphorylation of ULK1. In cells undergoing Ras-induced senescence (right), massive autophagosome formation initiates at the cell periphery (A). This may be due to the massive recruitment of mTORC1-positive lysosomes in the vicinity of the nucleus (B), resulting in de-inhibition of ULK1 at more distal locations. As autophagosomes mature, they fuse with mTORC1-positive lysosomes, giving rise to the TASCC (B). The flow of amino acids and other metabolites from autophagolysosomes activates mTORC1 (C), and also provides basic building blocks for protein synthesis. As a consequence, production of SMS components is upregulated at the endoplasmic reticulum and Golgi apparatus (D). Finally, SMS components are packaged into secretory vesicles at the trans-Golgi network and sent toward the plasma membrane (E); however, some newly-synthesized proteins are re-routed to the TASCC and rapidly degraded to fuel further rounds of protein synthesis. Abbreviations: TASCC = TOR-Autophagy Spatial Coupling Compartment; ER = endoplasmic reticulum; GA = Golgi apparatus; TGN = trans-Golgi network.
See this image and copyright information in PMC

Comment on

  • Spatial coupling of mTOR and autophagy augments secretory phenotypes.
    Narita M, Young AR, Arakawa S, Samarajiwa SA, Nakashima T, Yoshida S, Hong S, Berry LS, Reichelt S, Ferreira M, Tavaré S, Inoki K, Shimizu S, Narita M. Narita M, et al. Science. 2011 May 20;332(6032):966-70. doi: 10.1126/science.1205407. Epub 2011 Apr 21. Science. 2011. PMID: 21512002 Free PMC article.

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