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Review
. 2011 Aug;132(8-9):389-94.
doi: 10.1016/j.mad.2011.04.011. Epub 2011 May 11.

Cdk5: mediator of neuronal development, death and the response to DNA damage

Jinqiu Zhu  1 , Wenming Li, Zixu Mao
Affiliations
Review

Cdk5: mediator of neuronal development, death and the response to DNA damage

Jinqiu Zhu et al. Mech Ageing Dev. 2011 Aug.

Abstract

In the central nervous system, cyclin-dependent kinase 5 (Cdk5), an unusual member of the Cdk family, is implicated in the regulation of various physiological processes ranging from neuronal survival, migration and differentiation, to synaptogenesis, synaptic plasticity and neurotransmission. Dysregulation of this kinase has been demonstrated to play a critical role in the pathogenic process of neurodegenerative disorders. DNA damage is emerging as an important pathological component in various neurodegenerative conditions. In this review, we discuss the recent progress regarding the regulation and roles of Cdk5 under physiological conditions, and its dysregulation under pathological conditions, especially in neuronal death mediated by DNA damage.

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Figures

Figure 1
Figure 1
Schematic representation demonstrates Cdk5-mediated neuronal death in response to neurotoxic signals.
See this image and copyright information in PMC

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