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. 2011 Jul 7;47(25):7212-4.
doi: 10.1039/c1cc11967b. Epub 2011 May 23.

Highly enantioselective organocascade intermolecular iminium/enamine Michael addition on enals

Adrien Quintard  1 , Alexandre Alexakis
Affiliations

Highly enantioselective organocascade intermolecular iminium/enamine Michael addition on enals

Adrien Quintard et al. Chem Commun (Camb). .

Abstract

An unprecedented intermolecular iminium/enamine Michael addition on enals has been developed by taking advantage of the high reactivity of vinyl sulfones. This powerful organocascade allows for the rapid construction of attractive synthons in high enantioselectivities (typically 99% ee).

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