Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Oct;258(10):1763-74.
doi: 10.1007/s00415-011-6104-z. Epub 2011 May 22.

The role of mitochondria in neurodegenerative diseases

Massimiliano Filosto  1 , Mauro Scarpelli, Maria Sofia Cotelli, Valentina Vielmi, Alice Todeschini, Valeria Gregorelli, Paola Tonin, Giuliano Tomelleri, Alessandro Padovani
Affiliations
Review

The role of mitochondria in neurodegenerative diseases

Massimiliano Filosto et al. J Neurol. 2011 Oct.

Abstract

Mitochondria are implicated in several metabolic pathways including cell respiratory processes, apoptosis, and free radical production. Mitochondrial abnormalities have been documented in neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's diseases, and amyotrophic lateral sclerosis. Several studies have demonstrated that mitochondrial impairment plays an important role in the pathogenesis of this group of disorders. In this review, we discuss the role of mitochondria in the main neurodegenerative diseases and review the updated knowledge in this field.

PubMed Disclaimer

References

    1. Brain. 2006 Jul;129(Pt 7):1720-31 - PubMed
    1. Neurology. 2007 Jan 2;68(1):56-8 - PubMed
    1. J Neurochem. 2006 Jun;97(6):1659-75 - PubMed
    1. Mitochondrion. 2005 Apr;5(2):77-87 - PubMed
    1. Mitochondrion. 2006 Dec;6(6):323-30 - PubMed

LinkOut - more resources