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. 2011 Jun 27;50(27):6167-70.
doi: 10.1002/anie.201101684. Epub 2011 May 23.

Palladium-catalyzed diastereo- and enantioselective synthesis of substituted cyclopentanes through a dynamic kinetic asymmetric formal [3+2]-cycloaddition of vinyl cyclopropanes and alkylidene azlactones

Barry M Trost  1 , Patrick J Morris
Affiliations

Palladium-catalyzed diastereo- and enantioselective synthesis of substituted cyclopentanes through a dynamic kinetic asymmetric formal [3+2]-cycloaddition of vinyl cyclopropanes and alkylidene azlactones

Barry M Trost et al. Angew Chem Int Ed Engl. .
No abstract available

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Figures

Figure 1
Figure 1. Trost asymmetric allylic alkylation ligands
Scheme 1
Scheme 1
Palladium-catalyzed addition of vinyl cyclopropanes 1 to electron poor olefins.
Scheme 2
Scheme 2. Mechanistic rationale
Scheme 3
Scheme 3
Functionalization of cycloadduct for crystallographic analysis.
Scheme 4
Scheme 4
One step functionalization to bicyclic system.
See this image and copyright information in PMC

References

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