Review
doi: 10.1586/erv.11.32.
A combination recombinant protein and outer membrane vesicle vaccine against serogroup B meningococcal disease
Affiliations
- PMID: 21604979
- DOI: 10.1586/erv.11.32
Item in Clipboard
Review
A combination recombinant protein and outer membrane vesicle vaccine against serogroup B meningococcal disease
Expert Rev Vaccines.
2011 May.
Abstract
Although meningococcal disease caused by serogroup B remains an important public health concern, a licensed vaccine providing broad protection against this pathogen is not yet available. Advances in genomics have paved the way for the discovery of new vaccine candidates for inclusion into a multicomponent serogroup B vaccine. In this article, we will review recent advances in the development of these vaccines, focussing particularly on one of the 'next generation' MenB vaccines, 4CMenB.
Similar articles
-
Genetic shifts of Neisseria meningitidis serogroup B antigens and the quest for a broadly cross-protective vaccine.Expert Rev Vaccines. 2010 Oct;9(10):1203-17. doi: 10.1586/erv.10.116. Expert Rev Vaccines. 2010. PMID: 20923270 Review.
-
Bactericidal antibody against a representative epidemiological meningococcal serogroup B panel confirms that MATS underestimates 4CMenB vaccine strain coverage.Vaccine. 2013 Oct 9;31(43):4968-74. doi: 10.1016/j.vaccine.2013.08.006. Epub 2013 Aug 14. Vaccine. 2013. PMID: 23954380
-
Potential benefits of using a multicomponent vaccine for prevention of serogroup B meningococcal disease.Int J Infect Dis. 2019 Aug;85:22-27. doi: 10.1016/j.ijid.2019.05.019. Epub 2019 May 16. Int J Infect Dis. 2019. PMID: 31102824 Review.
-
Susceptibility of Meningococcal Strains Responsible for Two Serogroup B Outbreaks on U.S. University Campuses to Serum Bactericidal Activity Elicited by the MenB-4C Vaccine.Clin Vaccine Immunol. 2015 Dec;22(12):1227-34. doi: 10.1128/CVI.00474-15. Epub 2015 Sep 30. Clin Vaccine Immunol. 2015. PMID: 26424832 Free PMC article.
-
Immunogenicity of two investigational serogroup B meningococcal vaccines in the first year of life: a randomized comparative trial.Pediatr Infect Dis J. 2010 Nov;29(11):e71-9. doi: 10.1097/INF.0b013e3181f59f6d. Pediatr Infect Dis J. 2010. PMID: 20844462 Clinical Trial.
Cited by
-
Vaccines against meningococcal serogroup B disease containing outer membrane vesicles (OMV): lessons from past programs and implications for the future.Hum Vaccin Immunother. 2013 Jun;9(6):1241-53. doi: 10.4161/hv.24129. Epub 2013 Mar 7. Hum Vaccin Immunother. 2013. PMID: 23857274 Free PMC article. Review.
-
From genes to vaccine: A breakthrough in the prevention of meningococcal group B disease.Paediatr Child Health. 2011 Oct;16(8):e61-4. doi: 10.1093/pch/16.8.e61. Paediatr Child Health. 2011. PMID: 23024591 Free PMC article.
-
Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody.Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17128-33. doi: 10.1073/pnas.1419686111. Epub 2014 Nov 17. Proc Natl Acad Sci U S A. 2014. PMID: 25404323 Free PMC article.
-
Isolation of Chlamydia trachomatis and membrane vesicles derived from host and bacteria.J Microbiol Methods. 2012 Nov;91(2):222-30. doi: 10.1016/j.mimet.2012.08.012. Epub 2012 Aug 30. J Microbiol Methods. 2012. PMID: 22960504 Free PMC article.
-
Interlaboratory standardization of the sandwich enzyme-linked immunosorbent assay designed for MATS, a rapid, reproducible method for estimating the strain coverage of investigational vaccines.Clin Vaccine Immunol. 2012 Oct;19(10):1609-17. doi: 10.1128/CVI.00202-12. Epub 2012 Aug 8. Clin Vaccine Immunol. 2012. PMID: 22875603 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
