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Multicenter Study
. 2011 Aug 15;188(3):372-6.
doi: 10.1016/j.psychres.2011.05.006. Epub 2011 May 24.

Suicidal ideation in Huntington disease: the role of comorbidity

Heather H Wetzel  1 , Carissa R Gehl, Lisa Dellefave-Castillo, Judith F Schiffman, Kathleen M Shannon, Jane S Paulsen; Huntington Study Group
Collaborators, Affiliations
Multicenter Study

Suicidal ideation in Huntington disease: the role of comorbidity

Heather H Wetzel et al. Psychiatry Res. .

Abstract

Huntington disease (HD) is a neurodegenerative condition characterized by cognitive impairments, motor abnormalities, and psychiatric disturbance. An increased risk for suicide has been documented. The majority of HD research has focused on cognitive and motor features of HD; the implications of psychiatric manifestations have received less consideration. Recent studies have sought to identify the stages of HD in which patients are at increased risk to experience suicidal ideation, though no study has examined possible risk factors for suicidality. The current study examines the presence of psychiatric comorbidity and its involvement in suicidal ideation. Suicidal ideation was examined in 1941 HD patients enrolled in the Huntington Study Group. Of those, 19% (N=369) endorsed current suicidal ideation. Logistic regression analyses indicated that depression/anxiety and aggression/irritability are significant predictors of suicidal ideation. In a subsample with the greatest suicidal ideation, alcohol and drug abuse were also predictive. It is recommended that all individuals with HD (specifically those with features of depression, aggression, substance abuse) have routine suicide assessment; further research is needed to understand the high rate of suicide in HD.

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References

    1. Almqvist EW, Brinkman RR, Wiggins S, Hayden MR. Canadian Collaborative Study of Predictive Testing, 2003. Psychological consequences and predictors of adverse events in the first 5 years after predictive testing for Huntington’s disease. Clinical Genetics. 64:300–309. - PubMed
    1. Anderson KE, Louis ED, Stern Y, Marder KS. Cognitive correlates of obsessive and compulsive symptoms in Huntington’s disease. American Journal of Psychiatry. 2001;158:799–801. - PubMed
    1. Beglinger LJ, Langbehn DR, Duff K, Stierman L, Black DW, Nehl C, Anderson K, Penziner E, Paulsen JS. Investigators of the Huntington Study Group, 2007. Probability of obsessive and compulsive symptoms in Huntington’s disease. Biological Psychiatry. 61:415–418. - PubMed
    1. Beglinger LJ, Paulsen JS, Watson DB, Wang C, Duff K, Langbehn DR, Moser DJ, Paulson HL, Aylward EH, Carlozzi NE, Queller S, Stout JC. Obsessive and compulsive symptoms in prediagnosed Huntington’s disease. Journal of Clinical Psychiatry. 2008;69:1758–1765. - PMC - PubMed
    1. Berrios GE, Wagle AC, Markova IS, Wagle SA, Ho LW, Rubinsztein DC, Whittaker J, Ffrench-Constant C, Kershaw A, Rosser A, Bak T, Hodges JR. Psychiatric symptoms and CAG repeats in neurologically asymptomatic Huntington’s disease gene carriers. Psychiatry Research. 2001;102:217–225. - PubMed

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