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. 1990 Jun;10(6):3277-9.
doi: 10.1128/mcb.10.6.3277-3279.1990.

Density-dependent nerve growth factor regulation of Gs-alpha RNA in pheochromocytoma 12 cells

G Tjaden  1 , A Aguanno, R Kumar, D Benincasa, R M Gubits, H Yu, K P Dolan
Affiliations

Density-dependent nerve growth factor regulation of Gs-alpha RNA in pheochromocytoma 12 cells

G Tjaden et al. Mol Cell Biol. 1990 Jun.

Abstract

Nerve growth factor (NGF) affects levels of the alpha subunit of the stimulatory G protein (Gs-alpha) in pheochromocytoma 12 cells in a bidirectional, density-dependent manner. Cells grown at high density responded to NGF treatment with increased levels of Gs-alpha mRNA and protein. Conversely, in cells grown in low-density cultures, levels of this mRNA were lowered by NGF treatment.

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