Regulation of beta-adrenergic response in human lymphocytes: agonist induced subsensitivity
- PMID: 216063
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Regulation of beta-adrenergic response in human lymphocytes: agonist induced subsensitivity
Res Commun Chem Pathol Pharmacol.
1978 Nov.
Abstract
The concentration of intracellular cAMP in lymphocytes is regulated by isoproterenol and PGE1. Preincubation of lymphocytes with isoproterenol leads to a loss of the response to beta-adrenergic agents but not to PGE1. Preincubation of lymphocytes with PGE1, however, affects the sensitivities both to isoproterenol and PGE1. A decrease of beta-adrenergic receptors was found in cells preincubated with isoproterenol but not with PGE1. Part of the abnormalities associated with PGE1-preincubated cells can be restored by treating the cells with theophylline.
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