Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jun;117(6):1323-1330.
doi: 10.1097/AOG.0b013e31821aa358.

Change in body mass index between pregnancies and the risk of gestational diabetes in a second pregnancy

Samantha F Ehrlich  1 , Monique M Hedderson, Juanran Feng, Erica R Davenport, Erica P Gunderson, Assiamira Ferrara
Affiliations

Change in body mass index between pregnancies and the risk of gestational diabetes in a second pregnancy

Samantha F Ehrlich et al. Obstet Gynecol. 2011 Jun.

Abstract

Objective: To estimate the association between interpregnancy change in body mass index (BMI) and the risk of gestational diabetes mellitus (GDM) in a second pregnancy.

Methods: In a retrospective cohort analysis of 22,351 women, logistic regression models provided adjusted estimates of the risk of GDM in women gaining 3.0 or more 2.0-2.9, and 1.0-1.9 BMI units, or losing 1.0-2.0 and more than 2.0 units between pregnancies (one BMI unit corresponds to 5.9 pounds for the average height [5 feet 4 inches] of the study population). Women with stable BMIs (±1.0 BMI unit) comprised the reference.

Results: For those with GDM in the first pregnancy, the age-adjusted risk of GDM in the second pregnancy was 38.19% (95% confidence interval [CI] 34.96-41.42); for those whose first pregnancy was not complicated by GDM, the risk was 3.52% (95% CI 3.27-3.76). Compared with women who remained stable, interpregnancy BMI gains were associated with an increased risk of GDM in the second pregnancy (odds ratio [OR] 1.71 [95% CI 1.42-2.07] for gaining 1.0-1.9 BMI units; OR 2.46 [95% CI 2.00-3.02] for 2.0-2.9 BMI units; and OR 3.40 [95% CI 2.81-4.12] for 3.0 or more BMI units). The loss of BMI units was associated with a lower risk of GDM only among women who were overweight or obese in the first pregnancy (OR 0.26 [95% CI 0.14-0.47] for the loss of at least 2.0 BMI units). In overweight and obese women, those with GDM in the first pregnancy that did not develop the condition again gained fewer BMI units than those experiencing recurrent GDM (mean change 0.66 [95% CI 0.25-1.07] compared with 2.00 [95% CI 1.56-2.43] BMI units, respectively).

Conclusion: Interpregnancy increases in BMI between the first and second pregnancy increases a woman's risk of GDM pregnancy.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Assembly of the analytic cohort, Kaiser Permanente Northern California Pregnancy Glucose Tolerance Registry.
Figure 2
Figure 2
Mean interpregnancy change in body mass index (BMI) units, by BMI in the first pregnancy and gestational diabetes status in the first and second pregnancies. Adjusted for age, race-ethnicity, place of birth, gestational age at the weight measurements, and interval between pregnancies. Kaiser Permanente Northern California Pregnancy Glucose Tolerance Registry, 1996 to 2006. *P<.001 for difference in the mean change in BMI units between women who were overweight or obese in the first pregnancy and women who were of normal weight in the first pregnancy among women who had gestational diabetes in the first pregnancy, but not the second pregnancy.
See this image and copyright information in PMC

References

    1. Metzger BE. Summary and recommendations of the Third International Workshop-Conference on Gestational Diabetes Mellitus. Diabetes. 1991;40(Suppl 2):197–201. - PubMed
    1. Kjos SL, Buchanan TA. Gestational diabetes mellitus. N Engl J Med. 1999 Dec 2;341(23):1749–56. - PubMed
    1. Jovanovic L, Pettitt DJ. Gestational diabetes mellitus. JAMA. 2001;286(20):2516–8. - PubMed
    1. O’Sullivan JB, Mahan CM. Criteria for the oral glucose tolerance test in pregnancy. Diabetes. 1964;13:278–85. - PubMed
    1. Metzger BE. Long-term outcomes in mothers diagnosed with gestational diabetes mellitus and their offspring. Clin Obstet Gynecol. 2007 Dec;50(4):972–9. - PubMed

Publication types