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. 2011 Jan;15(1):43-7.

Alterations of bone mineral metabolism of children with different cell lineage types of acute lymphoblastic leukaemia under chemotherapy

A Tragiannidis, Ch Dokos, V Sidi, Th Papageorgiou, D Koliouskas, M Karamouzis, Ch Papastergiou, I Tsitouridis, G Katzos, I Rousso, F Athanassiadou-Piperopoulou

Alterations of bone mineral metabolism of children with different cell lineage types of acute lymphoblastic leukaemia under chemotherapy

A Tragiannidis et al. Hippokratia. 2011 Jan.

Abstract

Background: Children with haematological malignancies such as acute lymphoblastic leukaemia (ALL) may have alteration of bone mineral metabolism therefore increased risk for osteopenia and osteoporosis.

Patients and methods: The purpose of this study was to examine the alterations of bone mineral metabolism in two groups of children (n=42) according to immunophenotyping (B-cell type, T-cell type) both quantitative (bone mineral density z-scores) and qualitative (serum osteocalcin - OC and carboxyl-terminal telopeptide of human type I collagen - ICTP) during diagnosis (T=0), after the intensified chemotherapy period (T=0.5) and the consolidation period (T=1).

Results: According to our results 15 patients had osteopenia and 1 child developed osteoporosis at T=0.5 and 13 patients had osteopenia at T=1. Mean BMD z-score was significantly decreased in both groups during chemotherapy and especially statistically significant decline of T-cell type ALL group compared with B-cell type ALL patients. OC mean level remains in low levels for both groups reaching in plateau during chemotherapy and ICTP level was increased in T-cell type ALL group of patients compared with B-cell type in both periods of chemotherapy.

Conclusions: It seems that not only the combination of chemotherapeutic agents but also the cell lineage of ALL are important parameters of altering bone mineral metabolism.

Keywords: acute lymphoblastic leukemia; bone biochemical markers; bone mineral density; cell lineage; children.

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Figures

Figure 1
Figure 1. Alterations of mean BMD z-score at different periods of chemotherapy for T-cell and B-cell ALL patients
Figure 2
Figure 2. Mean BMD z-score curve during chemotherapy
Figure 3
Figure 3. Mean ICTP at different periods of chemotherapy T-cell and B-cell ALL patients
Figure 4
Figure 4. Mean ICTP curve during chemotherapy
Figure 5
Figure 5. Mean OC at different periods of chemotherapy T-cell and B-cell ALL patients
Figure 6
Figure 6. Mean OC curve during chemotherapy
See this image and copyright information in PMC

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