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. 2010 Apr 26;2(2):34-8.
doi: 10.4252/wjsc.v2.i2.34.

Application of human umbilical cord blood-derived mesenchymal stem cells in disease models

Ju-Yeon Kim  1 , Hong Bae Jeon, Yoon Sun Yang, Wonil Oh, Jong Wook Chang
Affiliations

Application of human umbilical cord blood-derived mesenchymal stem cells in disease models

Ju-Yeon Kim et al. World J Stem Cells. .

Abstract

Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) are regarded as an alternative source of bone marrow-derived mesenchymal stem cells because collection of cord blood is less invasive than that of bone marrow. hUCB-MSCs have recently been studied for evaluation of their potential as a source of cell therapy. In this review, the general characteristics of hUCB-MSCs and their therapeutic effects on various diseases in vitro and in vivo will be discussed.

Keywords: Immune modulation; Mesenchymal stem cells; Nursing effect; Regeneration.

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Figures

Figure 1
Figure 1
Multifunctional therapeutic activities of human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs). Transplanted hUCB-MSCs participate in cartilage, lung and liver regeneration through differentiation of damaged tissues as well as attenuation of inflammation and apoptosis. Interestingly, hUCB-MSCs can migrate toward glioma. When migrated hUCB-MSCs express apoptotic gene such as TRAIL in glioma region, tumor size will be decreased by secreted TRAIL from hUCB-MSCs.
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