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. 2011 Jun;43(6):897-9.
doi: 10.1002/mus.22037.

Electrical conduction block in large nerves: high-frequency current delivery in the nonhuman primate

D Michael Ackermann Jr  1 , Christian Ethier, Emily L Foldes, Emily R Oby, Dustin Tyler, Matt Bauman, Niloy Bhadra, Lee Miller, Kevin L Kilgore
Affiliations

Electrical conduction block in large nerves: high-frequency current delivery in the nonhuman primate

D Michael Ackermann Jr et al. Muscle Nerve. 2011 Jun.

Abstract

Recent studies have made significant progress toward the clinical implementation of high-frequency conduction block (HFB) of peripheral nerves. However, these studies were performed in small nerves, and questions remain regarding the nature of HFB in large-diameter nerves. This study in nonhuman primates shows reliable conduction block in large-diameter nerves (up to 4.1 mm) with relatively low-threshold current amplitude and only moderate nerve discharge prior to the onset of block.

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Figures

Figure 1
Figure 1
a) Finger flexor force during HFAC block threshold trial on the left median nerve in the m. mulatta monkey at a frequency of 30 kHz. Relative HFAC amplitude is indicated diagrammatically. HFAC amplitude started at 15.0 V, and threshold was measured to be 10.6 V (the arrow indicates the first twitch resulting from partial conduction block). b) Table summarizing the results of the randomized block threshold and onset response trials for each of the three nerves tested. The waveform generator was unable to produce sufficient amplitude to produce a complete conduction block at 40 kHz for the 4.1 mm nerve.
See this image and copyright information in PMC

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