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. 2011 Jul;34(1):56-9.
doi: 10.1002/jmri.22621. Epub 2011 May 23.

Impact of magnetic resonance imaging on cardiac mortality in thalassemia major

Giorgos Chouliaras  1 , Vasilios Berdoukas, Vassilis Ladis, Antonis Kattamis, Antonia Chatziliami, Christina Fragodimitri, Fotis Karabatsos, Jacqueline Youssef, Markissia Karagiorga-Lagana
Affiliations

Impact of magnetic resonance imaging on cardiac mortality in thalassemia major

Giorgos Chouliaras et al. J Magn Reson Imaging. 2011 Jul.

Abstract

Purpose: To evaluate whether the introduction of magnetic resonance imaging (MRI) in the management of thalassemia major (TM) patients has affected the risk of cardiac death.

Materials and methods: In all, 804 TM patients from two large reference units were included and the risk of dying of cardiac causes, before and after their first MRI, was assessed by a Cox proportional hazards model with time-dependent covariates.

Results: Adding information from MRI reduced the risk of cardiac death from 6.0 deaths/1000 patient-years to 3.9 deaths/1000 patient-years (P = 0.22). The risk of cardiac death before having an MRI study was 82% higher compared to the risk observed after the first MRI.

Conclusion: MRI has become a vital component of ongoing management and seems to have a beneficial effect on cardiac mortality in TM.

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