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Comment
. 2011 Jun;14(6):669-70.
doi: 10.1038/nn.2853.

Amyloid by default

Lary C Walker, Mathias Jucker
Comment

Amyloid by default

Lary C Walker et al. Nat Neurosci. 2011 Jun.

Abstract

The sustained metabolic activation of the brain’s default-mode network is thought to render the system vulnerable to Alzheimer’s disease. Recent results with transgenic mice support this view by linking neuronal activity to interstitial fluid amyloid-β levels and the development of amyloid-β plaques.

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Figures

Figure 1:
Figure 1:. Aβ and senile plaque formation in the default mode network.
Sustained neuronal activity and elevated aerobic glycolysis in brain areas such as the default-mode network (orange) are thought to be linked to elevated abundance of Aβ and augmented formation of senile (Aβ) plaques compared with those in brain regions with more intermittent, task-directed activation (blue). (The depiction of network activity in the brain is based on reference 3.)
See this image and copyright information in PMC

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References

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