Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Oct;23(10):1528-33.
doi: 10.1016/j.cellsig.2011.05.008. Epub 2011 May 15.

Mitochondrial stress: a bridge between mitochondrial dysfunction and metabolic diseases?

Fang Hu  1 , Feng Liu
Affiliations
Review

Mitochondrial stress: a bridge between mitochondrial dysfunction and metabolic diseases?

Fang Hu et al. Cell Signal. 2011 Oct.

Abstract

Under pathophysiological conditions such as obesity, excessive oxidation of nutrients may induce mitochondrial stress, leading to mitochondrial unfolded protein response (UPR(mt)) and initiation of a retrograde stress signaling pathway. Defects in the UPR(mt) and the retrograde signaling pathways may disrupt the integrity and homeostasis of the mitochondria, resulting in endoplasmic reticulum stress and insulin resistance. Improving the capacity of mitochondria to reduce stress may be an effective approach to improve mitochondria function and to suppress obesity-induced metabolic disorders such as insulin resistance and type 2 diabetes.

PubMed Disclaimer

References

    1. Pollex RL, Hegele RA. Nat Clin Pract Cardiovasc Med. 2006;3:482–489. - PubMed
    1. Hinney A, Hebebrand J. Obes Facts. 2008;1:35–42. - PMC - PubMed
    1. Hebebrand J, Hinney A. Child Adolesc Psychiatr Clin N Am. 2009;18:83–94. - PubMed
    1. Hamilton MT, Hamilton DG, Zderic TW. Diabetes. 2007;56:2655–2667. - PubMed
    1. Ritz P, Berrut G. Diabetes Metab. 2005;31(Spec No 2):5S–67S. - PubMed