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Comment
. 2011 May 27;34(5):695-7.
doi: 10.1016/j.immuni.2011.05.004.

A new twist on the PYRIN Mediterranean coast

Luigi Franchi  1 , Gabriel Núñez
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A new twist on the PYRIN Mediterranean coast

Luigi Franchi et al. Immunity. .
Free article

Abstract

Familial Mediterranean fever is caused by mutations of the PYRIN protein. Chae et al. (2011) provide evidence for a ASC protein-dependent pathway of caspase-1 activation in which gain-of-function PYRIN mutations lead to IL-1β cytokine overproduction and inflammatory disease.

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