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. 1990;16(4-6):303-5.
doi: 10.1007/BF00842784.

Detection of inflammatory lesions with radiolabelled immunoglobulins

D Blok  1 , M von Ogtrop, J W Arndt, J A Camps, R I Feitsma, W Goedemans, E K Pauwels
Affiliations

Detection of inflammatory lesions with radiolabelled immunoglobulins

D Blok et al. Eur J Nucl Med. 1990.

Abstract

Previous reports on the use of radiolabelled immunoglobulins led us to undertake a pilot experiment in an animal model to investigate the potentials of Tc 99m-immunoglobulin scintigraphy in the detection of infectious foci. Mice infected in one leg with staphylococcus infection were injected with Tc 99m-immunoglobulin, Tc 99m-albumin or gallium citrate Ga 67. The results obtained by scintigraphy suggested a specific accumulation of radiolabelled immunoglobulin at the site of infection. Visualization of the infection and the image quality, especially the 6- and 24-h images, were clearly enhanced after the use of immunoglobulin preparations as compared with gallium.

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