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. 2011 May;11(2):97-102.
doi: 10.17305/bjbms.2011.2589.

Outpatient antihypertensive drug utilization in Canton Sarajevo during five years period (2004-2008) and adherence to treatment guidelines assessment

Tarik Catić  1 , Begler Begović
Affiliations

Outpatient antihypertensive drug utilization in Canton Sarajevo during five years period (2004-2008) and adherence to treatment guidelines assessment

Tarik Catić et al. Bosn J Basic Med Sci. 2011 May.

Abstract

Hypertension is chronic disease with high prevalence, which can successfully be treated with antihypertensive drugs. Previous researches have shown that existing hypertension treatment guidelines are not fully implemented in practice. We have analysed antihypertensive drug utilization in Canton Sarajevo during five-year period (2004-2008). Research findings are discussed in relation to expected drug utilization according to Canton Sarajevo treatment guidelines. Objective of this research is to examine prescription patterns of antihypertensive drugs in primary health care in Canton Sarajevo during five-year period. Based on study findings we did an estimation of adherence to local treatment guidelines, which are similar to those published globally. Drug utilization data were collected from the largest pharmacy (retail) chain, representing more than 80% of pharmacies in Canton Sarajevo. Following drug groups have been analyzed: diuretics, beta-blockers, calcium-channel-blockers, ACE-Inhibitors (plain and combinations), Angiotensin-II-antagonists and alpha-blockers. Drug utilization is expressed in number of defined daily dose (DDDs), defined daily dose per thousand inhabitants per day (DDD/TID), drug utilization 90% (DU90%) and value in euros. ACE-Inhibitors are most prescribed drug class; combination of ACE-Inhibitors and diuretics account 46% of total antihypertensive budget spending. ACEIs are followed by calcium-channel-blockers. Diuretics utilization is decreasing from 2006 and being replaced with beta-blockers. Diuretics, recommended as first line therapy, are ranked as third in total antihypertensive drug utilization. It is necessary to introduce follow-up and enforce adherence to developed treatment guideline. Drug utilization studies can be used as tool for assessment of treatment guidelines adherence in primary health care.

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Figures

FIGURE 1
FIGURE 1
Prevalence of hypertension in Federation of Bosnia and Herzegovina during 2004-2008 (rate per 100 000 inhabitants)
FIGURE 2
FIGURE 2
Trends of consumption antihypertensive drugs (therapeutic subgroups C02-C09) in Canton Sarajevo by years.
FIGURE 3
FIGURE 3
Drug utilization 90% (DU90%) for five most prescribed antihypertensive drugs and trends for Years 2004-2008
FIGURE 4
FIGURE 4
Cumulative DU90% for first ten most proscribed ATC subgroups during analysed period
See this image and copyright information in PMC

References

    1. 2003. World Health Organization (WHO)/International Society of Hypertension (ISH) statement on management of hypertension. J Hypertens. 2003;21:1983–1992. - PubMed
    1. Wolf-Maier K, Cooper RS, Banegas JR, et al. Hypertension Prevalence and Blood Pressure Levels in 6 European Countries, Canada, and the United States. JAMA. 2003;289(18):2363–2369. - PubMed
    1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365(9455):217–223. - PubMed
    1. Federal Office of Statistics. [accessed on 30.08.2009]. URL: http://www.fzs.ba/Podaci/us-troj11.htm .
    1. Chamber of Economy of Canton Sarajevo. [accessed on 30.08.2009]. URL: http://www.pksa.com.ba/bosanski/poslovni_ambijent/stanje_privrede_ks/sta... .

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