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Comment
. 2011 May 27;145(5):647-9.
doi: 10.1016/j.cell.2011.05.009.

PK-M2 Makes Cells Sweeter on HIF1

Daniel A Tennant  1
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PK-M2 Makes Cells Sweeter on HIF1

Daniel A Tennant. Cell. .
Free article

Abstract

The transcription factor hypoxia-inducible factor 1 (HIF1) facilitates the induction of enzymes necessary for anaerobic glycolysis. Luo et al. (2011) now identify pyruvate kinase (PK)-M2 as an intriguing new interacting partner for HIF1, revealing a potential mechanism for the Warburg effect, an elevation in aerobic glycolytic metabolism frequently observed in cancer.

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