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. 2011 Jul;205(1):55.e1-7.
doi: 10.1016/j.ajog.2011.03.037. Epub 2011 May 28.

Pregravid cardiometabolic risk profile and risk for gestational diabetes mellitus

Monique M Hedderson  1 , Jeanne A Darbinian, Charles P Quesenberry, Assiamira Ferrara
Affiliations

Pregravid cardiometabolic risk profile and risk for gestational diabetes mellitus

Monique M Hedderson et al. Am J Obstet Gynecol. 2011 Jul.

Abstract

Objective: The purpose of this study was to examine pregravid cardiometabolic profile and subsequent risk of gestational diabetes mellitus (GDM).

Study design: GDM cases (n = 199) and control subjects (n = 381) were selected from a cohort of women who took part in a multiphasic health checkup examination at Kaiser Permanente from 1984-1996 and who had a subsequent pregnancy and were matched by year and age at multiphasic health checkup examination and age at delivery.

Results: Pregravid measurements of serum glucose levels of 100-140 mg/dL, body mass index of ≥ 25.0 kg/m(2), and prehypertension/hypertension level were associated independently with GDM risk (odds ratios [OR], 4.8; 95% confidence interval [CI], 1.7-13.9; OR, 2.7; 95% CI, 1.6-4.3; and OR, 1.5; 95% CI, 1.0-2.3, respectively). The risk of GDM increased with the number of cardiometabolic risk factors (P < .001); adverse levels of both body mass index and glucose were associated with a 4.6-fold increased risk of GDM, compared with women with normal levels (P = .0001).

Conclusion: Pregravid cardiometabolic risk profile may help clinicians to identify high-risk women to target for primary prevention or early management of GDM.

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