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. 1990 Jul;177(1):375-9.
doi: 10.1016/0042-6822(90)90494-c.

Cellular mechanisms in the superinfection exclusion of vesicular stomatitis virus

K O Simon  1 , J J Cardamone Jr, P A Whitaker-Dowling, J S Youngner, C C Widnell
Affiliations

Cellular mechanisms in the superinfection exclusion of vesicular stomatitis virus

K O Simon et al. Virology. 1990 Jul.

Abstract

The superinfection exclusion of VSV has been studied and found to be caused by a combination of three distinct effects on endocytosis by VSV-infected cells: first, a decreased rate of formation of endocytic vesicles as judged by an inhibition of fluid-phase uptake at 2 hr postinfection; second, a decreased rate of internalization of receptor-bound ligands, which was detected at 4 hr postinfection; and third, a competition with newly synthesized virus for occupancy of coated pits, as indicated by electron microscopy of infected cells. At the same time that fluid-phase uptake decreased, numerous uncoated invaginations were observed at the cell surface.

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