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Review
. 2011 Jun 1;3(4):1457-62.
doi: 10.2741/236.

Alternatively spliced tissue factor pathway inhibitor: functional implications

Alan E Mast  1
Affiliations
Review

Alternatively spliced tissue factor pathway inhibitor: functional implications

Alan E Mast. Front Biosci (Schol Ed). .

Abstract

Tissue factor pathway inhibitor (TFPI) is a factor Xa dependent inhibitor of tissue factor initiated blood coagulation. In recent years several alternatively spliced forms of TFPI have been identified. These alternatively spliced forms have different C-terminal regions and have different mechanisms for association with cell surfaces. They are differentially expressed in human and mouse tissues and may have distinct physiological functions.

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Figures

Figure 1
Figure 1
The amino acid sequence and Kunitz domain structure of human TFPI alpha. Red circles indicate acidic amino acids. Blue circles indicate basic amino acids. Yellow circles are cysteine residues.
Figure 2
Figure 2
The amino acid sequence and Kunitz domain structure of human TFPI beta. Red circles indicate acidic amino acids. Blue circles indicate basic amino acids. Yellow circles are cysteine residues.
Figure 3
Figure 3
The amino acid sequence and Kunitz domain structure of human TFPI gamma. Red circles indicate acidic amino acids. Blue circles indicate basic amino acids. Yellow circles are cysteine residues.
Figure 4
Figure 4
The amino acid sequence and Kunitz domain structure of mouse TFPI delta. Red circles indicate acidic amino acids. Blue circles indicate basic amino acids. Yellow circles are cysteine residues.
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