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Comment
. 2011 Jun 3;332(6034):1149; author reply 1149.
doi: 10.1126/science.1201438. Epub 2011 May 27.

Comment on "A bacterium that can grow by using arsenic instead of phosphorus"

B Schoepp-Cothenet  1 , W Nitschke, L M Barge, A Ponce, M J Russell, A I Tsapin
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Comment

Comment on "A bacterium that can grow by using arsenic instead of phosphorus"

B Schoepp-Cothenet et al. Science. .

Abstract

Wolfe-Simon et al. (Research Articles, 3 June 2011, p. 1163; published online 2 December 2010) argued that the bacterial strain GFAJ-1 can vary the elemental composition of its biomolecules by substituting arsenic for phosphorus. Although their data show that GFAJ-1 is an extraordinary extremophile, consideration of arsenate redox chemistry undermines the suggestion that arsenate can replace the physiologic functions of phosphate.

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