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Comment
. 2011 Jul;13(4):622-3.
doi: 10.1038/aja.2011.50. Epub 2011 May 30.

Prostate cancer cells metastasize to the hematopoietic stem cell niche in bone

Evan T Keller  1
Affiliations
Comment

Prostate cancer cells metastasize to the hematopoietic stem cell niche in bone

Evan T Keller. Asian J Androl. 2011 Jul.
No abstract available

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Figures

Figure 1
Figure 1
Prostate cancer (PCa) competes with hematopoietic stem cells (HSCs) for the HSC niche. HSCs express annexin II receptor (AX2R) and CXCR4, the receptor for CXCL12. The chemokine, CXCL12, is produced by osteoblasts and induces chemotaxis of HSC to the HSC niche. The HSC docks onto the osteoblast, in part, through annexin II (AX2) binding to AX2R. PCa cells also express AX2R and CXCR4 which allows them to compete for binding to the osteoblast in the HSC niche inducing release of HSCs.
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