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. 2011 May 31;76(22):1894-902.
doi: 10.1212/WNL.0b013e31821d74fa.

Real-life driving outcomes in Parkinson disease

E Y Uc  1 , M Rizzo, A M Johnson, J L Emerson, D Liu, E D Mills, S W Anderson, J D Dawson
Affiliations

Real-life driving outcomes in Parkinson disease

E Y Uc et al. Neurology. .

Abstract

Objective: To determine the incidence of and risk factors for driving outcomes in drivers with Parkinson disease (PD).

Methods: In a prospective cohort study, we ascertained the time until driving cessation, a crash, or a traffic citation using self-report and state Department of Transportation records in 106 licensed, active drivers with PD and 130 controls.

Results: Drivers with PD stopped driving earlier than controls, hazard ratio (95% confidence interval) = 7.09 (3.66-13.75), p < 0.001. Cumulative incidence of driving cessation at 2 years after baseline was 17.6% (11.5%-26.5%) for PD and 3.1% (1.2%-8.1%) for controls. No significant differences between groups on times to first crash or citation were detected. However, the number of observed crashes was low. Cox proportional hazards models showed that significant baseline risk factors for driving cessation in PD were older age, preference to be driven by somebody else, positive crash history, use of compensatory strategies, low driving exposure, impairments in visual perception (especially visual processing speed and attention) and cognitive abilities, parkinsonism (especially activities of daily living score and total daily dose of antiparkinsonian medications), and higher error counts on a road test. Within PD, crashes were associated with poorer postural stability and history of driving citations, and citations were associated with younger age and road errors at baseline.

Conclusions: Drivers with PD are at a higher risk of driving cessation than elderly control drivers. A battery evaluating motor and nonmotor aspects of PD, driving record, and performance can be useful in assessing future driving outcomes in PD.

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Figures

Figure
Figure
Kaplan-Meier survival curves for driving cessation (log rank test χ2 = 37.53, p < 0.0001) between subjects with Parkinson disease and elderly control subjects
See this image and copyright information in PMC

References

    1. Uc EY, Rizzo M, Johnson AM, et al. Road safety in drivers with Parkinson disease. Neurology 2009;73:2112–2119 - PMC - PubMed
    1. Heikkila VM, Turkka J, Korpelainen J, et al. Decreased driving ability in people with Parkinson's disease. J Neurol Neurosurg Psychiatry 1998;64:325–330 - PMC - PubMed
    1. Wood JM, Worringham C, Kerr G, et al. Quantitative assessment of driving performance in Parkinson's disease. J Neurol Neurosurg Psychiatry 2005;76:176–180 - PMC - PubMed
    1. Grace J, Amick MM, D'Abreu A, et al. Neuropsychological deficits associated with driving performance in Parkinson's and Alzheimer's disease. J Int Neuropsychol Soc 2005;11:766–775 - PMC - PubMed
    1. Uc EY, Rizzo M, Anderson SW, et al. Driving with distraction in Parkinson disease. Neurology 2006;67:1774–1780 - PubMed

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