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Case Reports
. 2011;3(1):e2011010.
doi: 10.4084/MJHID.2011.010. Epub 2011 Mar 15.

Severe acute hepatitis B treated with entecavir

Giuseppe Vittorio Luigi De Socio  1 , Alessio Sgrelli, Andrea Tosti, Franco Baldelli
Affiliations
Case Reports

Severe acute hepatitis B treated with entecavir

Giuseppe Vittorio Luigi De Socio et al. Mediterr J Hematol Infect Dis. 2011.

Abstract

Hepatitis B virus (HBV) infection constitutes a serious global health problem. Nowadays there are divergent data regarding the use of antiviral drugs to treat acute hepatitis B. We present here a case of a 62-year-old man affected by severe acute hepatitis B with progressive worsening of clinical and hepatic function. The patient was treated with entecavir without critical side effects. We observed rapid clinical and laboratory improvements and the disappearance of hepatitis B surface antigen (HBsAg). The treatment with entecavir was protracted until 17(th) week when the antibody anti-HBs appeared. Entecavir should be carefully considered for the treatment of severe acute hepatitis B cases.

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Figures

Figure 1
Figure 1
Biochemical and viral parameters at admission and subsequent controls. Alanine aminotransferase (ALT) UI/mL, prothrombin time activity percentage (PT), hepatitis B antigen (HBsAg) UI/mL, antibody antiHBs (anti HBs), Hepatitis B DNA (HBV-DNA) UI/mL.
See this image and copyright information in PMC

References

    1. Wright TL, Lau JY. Clinical aspects of hepatitis B virus infection. Lancet. 1993;342:1340–1344. doi: 10.1016/0140-6736(93)92250-W. - DOI - PubMed
    1. Antoniu E, Luca V. Features of clinical evolution of severe acute viral hepatitis. Series of 72 cases. Rev Med Chir Soc Med Nat Iasi. 2010;114:95–100. - PubMed
    1. De Socio GV, Mercuri A, Di Candilo F, Baldelli F. Entecavir to treat severe acute hepatitis B. Scand J Infect Dis. 2009;41:703–704. doi: 10.1080/00365540903062705. - DOI - PubMed
    1. Yu JW, Sun LJ, Zhao YH, Kang P, Li SC. The study of efficacy of lamivudine in patients with severe acute hepatitis B. Dig Dis Sci. 2010;55:775–783. doi: 10.1007/s10620-009-1060-5. - DOI - PubMed
    1. Schiff E, Simsek H, Lee WM, Chao YC, Sette H, Jr, Janssen HL, Han SH, Goodman Z, Yang J, Brett-Smith H, Tamez R. Efficacy and safety of entecavir in patients with chronic hepatitis B and advanced hepatic fibrosis or cirrhosis. Am J Gastroenterology. 2008;103:2776–2783. doi: 10.1111/j.1572-0241.2008.02086.x. - DOI - PubMed

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