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. 2011 Jun;87(6):622-7.
doi: 10.3109/09553002.2011.570415.

Effect of dose-rate on induction of neoplastic transformation in vitro by low doses of 232 MeV protons

Eugene Elmore  1 , Xyoan Y Lao, Rubina L Kapadia, J Leslie Redpath
Affiliations

Effect of dose-rate on induction of neoplastic transformation in vitro by low doses of 232 MeV protons

Eugene Elmore et al. Int J Radiat Biol. 2011 Jun.

Abstract

Purpose: To determine the effect of dose-rate on induction of neoplastic transformation in vitro by low doses of 232 MeV protons.

Materials and methods: The experimental system used was the human hybrid cell assay. The dose-rates examined were 50 cGy/min and 20 cGy/h. The dose-rate 20 cGy/h was chosen as this is in the range of the maximum dose-rate that can be experienced in an unshielded space environment following a solar flare. At low dose-rate (LDR), doses from 0.5-100 cGy were studied. At high dose rate (HDR), the dose range was 0.5-200 cGy.

Results: The data indicated no significant differences between the two dose-rates at doses up to 100 cGy.

Conclusion: For the endpoint of neoplastic transformation in vitro, high dose-rate data may be sufficient to estimate low dose-rate effects (20 cGy/h) in the dose range up to 100 cGy from 232 MeV protons. The data are of relevance to risk estimation for space travel.

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