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Meta-Analysis
. 2011 Jul 1;204(1):74-83.
doi: 10.1093/infdis/jir196.

A systematic review and meta-analysis of interventions to prevent hepatitis C virus infection in people who inject drugs

Holly Hagan  1 , Enrique R Pouget, Don C Des Jarlais
Affiliations
Meta-Analysis

A systematic review and meta-analysis of interventions to prevent hepatitis C virus infection in people who inject drugs

Holly Hagan et al. J Infect Dis. .

Abstract

Introduction: High rates of hepatitis C virus (HCV) transmission are found in samples of people who inject drugs (PWID) throughout the world. The objective of this paper was to meta-analyze the effects of risk-reduction interventions on HCV seroconversion and identify the most effective intervention types.

Methods: We performed a systematic review and meta-analysis of published and unpublished studies. Eligible studies reported on the association between participation in interventions intended to reduce unsafe drug injection and HCV seroconversion in samples of PWID.

Results: The meta-analysis included 26 eligible studies of behavioral interventions, substance-use treatment, syringe access, syringe disinfection, and multicomponent interventions. Interventions using multiple combined strategies reduced risk of seroconversion by 75% (pooled relative risk, .25; 95% confidence interval, .07-.83). Effects of single-method interventions ranged from .6 to 1.6.

Conclusions: Interventions using strategies that combined substance-use treatment and support for safe injection were most effective at reducing HCV seroconversion. Determining the effective dose and combination of interventions for specific subgroups of PWID is a research priority. However, our meta-analysis shows that HCV infection can be prevented in PWID.

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References

    1. Gerberding JL. Incidence and prevalence of human immunodeficiency virus, hepatitis B virus, hepatitis C virus, and cytomegalovirus among health care personnel at risk for blood exposure: Final report from a longitudinal study. J Infect Dis. 1994;170:1410–7. - PubMed
    1. Hagan H, Pouget ER, Des Jarais DC, Lelutiu-Weinberger C. Meta-regression of hepatitis C virus infection in relation to time since onset of illicit drug injection: The influence of time and place. Am J Epidemiol. 2008;168:1099–109. - PMC - PubMed
    1. Eicher AD, Crofts N, Benjamin S, Deutschmann P, Rodger AJ. A certain fate: Spread of HIV among young injecting drug users in Manipur, north-east India. AIDS Care. 2000;12:497–504. - PubMed
    1. Kuo I, ul-Hasan S, Galai N, et al. High HCV seroprevalence and HIV drug use risk behaviors among injection drug users in Pakistan. Harm Reduct J. 2006;3:26. - PMC - PubMed
    1. van de Laar TJ, Langendam MW, Bruisten SM, et al. Changes in risk behavior and dynamics of hepatitis C virus infections among young drug users in Amsterdam, the Netherlands. J Med Virol. 2005;77:509–18. - PubMed

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