Novel strategies for managing infantile hemangiomas: a review

Abstract

Complicated infantile hemangiomas require early intervention. With the advent of an improved understanding of the pathophysiology of the condition, and the serendipitous discovery of the effects of propranolol, available treatment options have expanded from the traditional use of steroids. This article reviews the current literature on the treatment of complicated hemangiomas with steroids, interferon, vincristine, bleomycin, and propranolol. The likely mechanism of action, indications, recommended treatment regimes, and complications are discussed.