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. 2011 May 31;7(7):377-8.
doi: 10.1038/nrendo.2011.90.

Anomalous role for dietary salt in diabetes mellitus?

Volker Vallon, Scott C Thomson

Anomalous role for dietary salt in diabetes mellitus?

Volker Vallon et al. Nat Rev Endocrinol. .

Abstract

Prevailing guidelines advocate a low-salt diet to mitigate progression of kidney and cardiovascular disease in patients with diabetes mellitus. However, two recent cohort studies in patients with type 1 and type 2 diabetes mellitus associate lower salt intake with increased rates of end-stage renal disease, cardiovascular death and all-cause mortality.

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Figure 1
Figure 1
A conceptual framework that links a low salt intake to end-stage renal disease (ESRD) and cardiovascular mortality via the salt paradox in the diabetic kidney—that is, an inverse relationship between salt intake and glomerular hyperfiltration.
See this image and copyright information in PMC

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