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. 2011:2011:505607.
doi: 10.4061/2011/505607. Epub 2011 May 18.

What Are the bona fide GSK3 Substrates?

Calum Sutherland  1
Affiliations

What Are the bona fide GSK3 Substrates?

Calum Sutherland. Int J Alzheimers Dis. 2011.

Abstract

Nearly 100 proteins are proposed to be substrates for GSK3, suggesting that this enzyme is a fundamental regulator of almost every process in the cell, in every tissue in the body. However, it is not certain how many of these proposed substrates are regulated by GSK3 in vivo. Clearly, the identification of the physiological functions of GSK3 will be greatly aided by the identification of its bona fide substrates, and the development of GSK3 as a therapeutic target will be highly influenced by this range of actions, hence the need to accurately establish true GSK3 substrates in cells. In this paper the evidence that proposed GSK3 substrates are likely to be physiological targets is assessed, highlighting the key cellular processes that could be modulated by GSK3 activity and inhibition.

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Figures

Figure 1
Figure 1
Different signaling pathways regulate GSK3 activity by different mechanisms, and this could permit differential regulation of GSK3 substrate phosphorylation.
Figure 2
Figure 2
Potential physiological and pathological effects of phosphorylation of proposed GSK3 substrates.
See this image and copyright information in PMC

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