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Case Reports
. 2012 Feb;79(2):256-9.
doi: 10.1007/s12098-011-0481-2. Epub 2011 Jun 1.

Acute myeloid leukemia (AML-M2) with translocation (8;21) (q22;q22) and abnormal eosinophilic precursors in the bone marrow--a case report

Oneal Gupta  1 , Roopak Aggarwal, Rajni Prasad
Affiliations
Case Reports

Acute myeloid leukemia (AML-M2) with translocation (8;21) (q22;q22) and abnormal eosinophilic precursors in the bone marrow--a case report

Oneal Gupta et al. Indian J Pediatr. 2012 Feb.

Abstract

The translocation (8;21)(q22;q22) is frequently associated with M2 subtype of AML. The authors herein present a case of AML-M2 in a nine-year-old boy without hepatosplenomegaly, lymphadenopathy or any bleeding diathesis. Bone marrow examination revealed high number of eosinophilic precursors (60%) among the total nucleated bone marrow cells. Cytogenetic study with G- banding method showed 46, XY, t (8;21)(q22;q22). The morphological abnormalities in eosinophils observed in AML suggested that eosinophils may be a part of leukemic process.

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