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. 2011 Jul;34(7):442-6.
doi: 10.1002/clc.20905. Epub 2011 May 31.

The coexistence of multiple cardiovascular diseases is an independent predictor of the 30-day mortality of hospitalized patients with congestive heart failure: a study in Beijing

Qiaoxiang Yin  1 , Yusheng Zhao, Jiayue Li, Qiao Xue, Xingli Wu, Lei Gao, Ping He, Mei Zhu, Shiwen Wang
Affiliations

The coexistence of multiple cardiovascular diseases is an independent predictor of the 30-day mortality of hospitalized patients with congestive heart failure: a study in Beijing

Qiaoxiang Yin et al. Clin Cardiol. 2011 Jul.

Abstract

Background: Congestive heart failure (CHF) has become a major clinical and public health challenge with the aging of the population in China. However, the effect of the coexistence of multiple cardiovascular diseases on the prognosis of hospitalized patients with CHF remains unclear. A comparative analysis was performed to explore the etiology and comorbidities of CHF and in-hospital mortality in patients with CHF.

Hypothesis: The coexistence of multiple cardiovascular diseases is an independent predictor of the 30-day mortality of hospitalized patients with CHF.

Methods: All 6949 patients (4344 males, 2605 females) in the database with a principal ICD-9-CM discharge diagnosis of CHF were identified and divided into 5 groups according to the number of comorbidities. Cox proportional hazards regression was used to examine the association between the number of comorbidities and in-hospital mortality in patients with CHF.

Results: A single comorbidity was predominant in younger patients (18-39 years, P<0.001), whereas multiple comorbidities were predominant in the elderly (≥80 years, P<0.001). The most common single etiology was valvular heart disease, and the most common triple etiology was hypertension and diabetes mellitus complicated by coronary artery disease. Cox regression analysis showed a higher hospital mortality rate associated with an increased number of comorbidities (hazard ratio [HR] from 1.22 [95% CI: 0.89-1.68] to HR 3.49 [95% CI: 2.55-4.78], P<0.001).

Conclusions: This study demonstrates the coexistence of multiple cardiovascular diseases is an independent predictor of the 30-day mortality of hospitalized patients with CHF.

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Figures

Figure 1
Figure 1
Etiology of congestive heart failure in patients hospitalized.
Figure 2
Figure 2
Distribution of comorbidity number among hospitalized patients with congestive heart failure by age.
Figure 3
Figure 3
Age and comorbidity distribution of 30‐day mortality.
Figure 4
Figure 4
In‐hospital mortality curves according to comorbidities by Cox regression analysis. Abbreviations: CI, confidence interval; HR, hazard ratio.
See this image and copyright information in PMC

References

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