Thematic minireview series on biological applications of mass spectrometry
- PMID: 21632545
- PMCID: PMC3138286
- DOI: 10.1074/jbc.R111.266700
Thematic minireview series on biological applications of mass spectrometry
Abstract
Mass spectrometry is a powerful technique with many applications in biology as well as chemistry and physics. The increases in sensitivity and resolution of the instruments, coupled with improvements in the analysis of data, have opened new dimensions in analyses of complex biological systems. Examples presented here include drug metabolism, lipid analysis, metabolomics, quantitative proteomics, direct analysis of intact proteins, and imaging of both small molecules and proteins in tissues.
Comment on
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Liquid chromatography-mass spectrometry-based quantitative proteomics.J Biol Chem. 2011 Jul 22;286(29):25443-9. doi: 10.1074/jbc.R110.199703. Epub 2011 Jun 1. J Biol Chem. 2011. PMID: 21632532 Free PMC article. Review.
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New applications of mass spectrometry in lipid analysis.J Biol Chem. 2011 Jul 22;286(29):25427-33. doi: 10.1074/jbc.R111.233478. Epub 2011 Jun 1. J Biol Chem. 2011. PMID: 21632539 Free PMC article. Review.
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Mass spectrometry strategies in metabolomics.J Biol Chem. 2011 Jul 22;286(29):25435-42. doi: 10.1074/jbc.R111.238691. Epub 2011 Jun 1. J Biol Chem. 2011. PMID: 21632543 Free PMC article. Review.
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Drug metabolite profiling and identification by high-resolution mass spectrometry.J Biol Chem. 2011 Jul 22;286(29):25419-25. doi: 10.1074/jbc.R110.200055. Epub 2011 Jun 1. J Biol Chem. 2011. PMID: 21632546 Free PMC article. Review.
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Imaging of intact tissue sections: moving beyond the microscope.J Biol Chem. 2011 Jul 22;286(29):25459-66. doi: 10.1074/jbc.R111.225854. Epub 2011 Jun 1. J Biol Chem. 2011. PMID: 21632549 Free PMC article. Review.
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Analysis of intact protein isoforms by mass spectrometry.J Biol Chem. 2011 Jul 22;286(29):25451-8. doi: 10.1074/jbc.R111.239442. Epub 2011 Jun 1. J Biol Chem. 2011. PMID: 21632550 Free PMC article. Review.
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