Cell-mediated immune responses to poliovirus II. Survey of delayed hypersensitivity and T-cell proliferative responses in inbred mouse strains

Abstract

Some epidemiological reports suggest a human genetic predisposition for susceptibility to the development of paralytic poliomyelitis. In a previous study of cell-mediated immune responses by mice to poliovirus (PV), we showed differences in the responses by BALB/c and C57BL/6 (B6) mice. The present study is a further analysis of the delayed hypersensitivity (DTH) and T cell proliferative (Tprlf) responses to PV in 17 different inbred strains of mice, to determine if these responses were under major histocompatibility complex (MHC) or other genetic control. Both DTH and Tprlf to PV did not correlate with MHC for responses to any of the three PV serotypes. Further, we found a lack of concordance of DTH and Tprlf responses to a given PV serotype. The cell-mediated immune responses by any one mouse strain to one PV serotype is not predictive of that mouse strain's response to another PV serotype.