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Review
. 2011 Jun;78(6):358-73.
doi: 10.3949/ccjm.78gr.10005.

Immune thrombocytopenia: no longer 'idiopathic'

Keith McCrae  1
Affiliations
Review

Immune thrombocytopenia: no longer 'idiopathic'

Keith McCrae. Cleve Clin J Med. 2011 Jun.

Abstract

Immune thrombocytopenia (ITP) is a common hematologic disorder. Its pathogenesis involves both accelerated platelet destruction and impaired platelet production. First-line agents are usually effective initially but do not provide long-term responses. Splenectomy remains an effective long-term therapy, as does rituximab (Rituxan) in a subset of patients. Thrombopoietic agents offer a new alternative, although their place in the overall management of ITP remains uncertain.

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References

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