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. 2011 Jun 2;12(7):407-12.
doi: 10.1038/nrm3133.

A blueprint for kinetochores - new insights into the molecular mechanics of cell division

Fabienne Lampert  1 , Stefan Westermann
Affiliations

A blueprint for kinetochores - new insights into the molecular mechanics of cell division

Fabienne Lampert et al. Nat Rev Mol Cell Biol. .

Abstract

Kinetochores are large proteinaceous complexes that physically link centromeric DNA to the plus ends of spindle microtubules. Stable kinetochore-microtubule attachments are a prerequisite for the accurate and efficient distribution of genetic material over multiple generations. In the past decade, concerted research has resulted in the identification of the individual kinetochore building blocks, the characterization of critical microtubule-interacting components, such as the NDC80 complex, and the development of an approximate model of the architecture of this sophisticated biological machine.

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References

    1. J Cell Biol. 2007 Jul 16;178(2):269-81 - PubMed
    1. J Biol Chem. 2003 Sep 19;278(38):36430-4 - PubMed
    1. Nat Cell Biol. 2006 Jun;8(6):581-5 - PubMed
    1. Dev Cell. 2009 Mar;16(3):374-85 - PubMed
    1. Curr Biol. 2011 Feb 8;21(3):207-13 - PubMed

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