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Case Reports
. 2011 May 14;17(18):2349-52.
doi: 10.3748/wjg.v17.i18.2349.

Lapatinib-induced hepatitis: a case report

Stavros Peroukides  1 , Thomas Makatsoris, Angelos Koutras, Athanasios Tsamandas, Adimchi Onyenadum, Chryssoula Labropoulou-Karatza, Haralabos Kalofonos
Affiliations
Case Reports

Lapatinib-induced hepatitis: a case report

Stavros Peroukides et al. World J Gastroenterol. .

Abstract

Lapatinib is an inhibitor of the tyrosine kinases of human epidermal growth factor receptor type 2 (HER2) and epidermal growth factor receptor type 1, with clinical activity in HER2-positive metastatic breast cancer. We present here a 60 year-old patient with metastatic breast cancer who presented with jaundice and increased serum aminotransferase levels and who had been treated with lapatinib for the previous 14 days. Laboratory tests excluded other causes of acute liver injury. Liver biopsy revealed lesions compatible with drug-induced hepatotoxicity. Bilirubin and liver enzymes returned to normal within three months of lapatinib discontinuation. Lapatinib should be included among the causes of drug-induced hepatitis.

Keywords: Breast cancer; Hepatitis; Hepatotoxicity; Human epidermal growth factor receptor type 2; Lapatinib.

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Figures

Figure 1
Figure 1
Photomicrograph. A: Areas of bridging necrosis (HE x 200); B: Areas of centrilobular hepatocellular dropout, hemorrhage and macrophages (HE x 200).
See this image and copyright information in PMC

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